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Microwave-Assisted Cleavage of Cysteine Perfluoroaryl Thioethers

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Published as: Bednar, Taylor N., Alissa R. Resnikoff, and Jason Gavenonis. Microwave-Assisted Cleavage of Cysteine Perfluoroaryl Thioethers. Amino Acids 52 (2020): 841-845. https://doi.org/10.1007/s00726-020-02846-z This author post-print is made available on Dickinson Scholar with the permission of the publisher. For more information on the published version, visit Springer's Website. To access a view-only full text published version of this article click here. Online access to this article has been shared by the author(s) via Springer Nature SharedIt.

The cysteine- perfluoroarene SNAr reaction allows for the sequence-specific attachment of dyes and affinity tags to peptides and proteins. However, while many methods exist for the desulfuration of native and functionalized cysteine residues, there are no reports of their application to perfluoroarylated cysteines. Herein we report both the hydrogenolysis of a perfluoroarylated cysteine to alanine and elimination to dehydroalanine, reactions that are both accelerated by microwave irradiation.

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MLA citation style (9th ed.)

Bednar, Taylor N, Gavenonis, Jason, and Resnikoff, Alissa R. Microwave-assisted Cleavage of Cysteine Perfluoroaryl Thioethers. . 2020. dickinson.hykucommons.org/concern/generic_works/545428ce-9937-49c9-9009-947f5b4bafbe?q=2020.

APA citation style (7th ed.)

B. T. N, G. Jason, & R. A. R. (2020). Microwave-Assisted Cleavage of Cysteine Perfluoroaryl Thioethers. https://dickinson.hykucommons.org/concern/generic_works/545428ce-9937-49c9-9009-947f5b4bafbe?q=2020

Chicago citation style (CMOS 17, author-date)

Bednar, Taylor N., Gavenonis, Jason, and Resnikoff, Alissa R.. Microwave-Assisted Cleavage of Cysteine Perfluoroaryl Thioethers. 2020. https://dickinson.hykucommons.org/concern/generic_works/545428ce-9937-49c9-9009-947f5b4bafbe?q=2020.

Note: These citations are programmatically generated and may be incomplete.

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